Functional Circuitry Effect of Ventral Tegmental Area Deep Brain Stimulation: Imaging and Neurochemical Evidence of Mesocortical and Mesolimbic Pathway Modulation

@inproceedings{Settell2017FunctionalCE,
  title={Functional Circuitry Effect of Ventral Tegmental Area Deep Brain Stimulation: Imaging and Neurochemical Evidence of Mesocortical and Mesolimbic Pathway Modulation},
  author={Megan L. Settell and Paola Testini and Shinho Cho and Jannifer H. Lee and Charles D. Blaha and Hang Joon Jo and Kendall H. Lee and Hoon-Ki Min},
  booktitle={Frontiers in neuroscience},
  year={2017}
}
Background: The ventral tegmental area (VTA), containing mesolimbic and mesocortical dopaminergic neurons, is implicated in processes involving reward, addiction, reinforcement, and learning, which are associated with a variety of neuropsychiatric disorders. Electrical stimulation of the VTA or the medial forebrain bundle and its projection target the nucleus accumbens (NAc) is reported to improve depressive symptoms in patients affected by severe, treatment-resistant major depressive disorder… CONTINUE READING
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