Functional Characterization of the β-Adrenergic Receptor Subtypes Expressed by CA1 Pyramidal Cells in the Rat Hippocampus

@article{Hillman2005FunctionalCO,
  title={Functional Characterization of the $\beta$-Adrenergic Receptor Subtypes Expressed by CA1 Pyramidal Cells in the Rat Hippocampus},
  author={Kristin L. Hillman and Van A. Doze and James E. Porter},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={314},
  pages={561 - 567}
}
Recent studies have demonstrated that activation of the β-adrenergic receptor (AR) using the selective β-AR agonist isoproterenol (ISO) facilitates pyramidal cell long-term potentiation in the cornu ammonis 1 (CA1) region of the rat hippocampus. We have previously analyzed β-AR genomic expression patterns of 17 CA1 pyramidal cells using single cell reverse transcription-polymerase chain reaction, demonstrating that all samples expressed the β2-AR transcript, with four of the 17 cells… 
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β1 Adrenergic Receptor-Mediated Enhancement of Hippocampal CA3 Network Activity
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This pharmacological profile of subtype-selective βAR antagonists indicates that in this model, β1AR activation is responsible for the enhanced hippocampal CA3 network activity initiated by isoproterenol.
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