Functional Characterization of TLR4 +3725 G/C Polymorphism and Association with Protection against Overweight

@inproceedings{PenasSteinhardt2012FunctionalCO,
  title={Functional Characterization of TLR4 +3725 G/C Polymorphism and Association with Protection against Overweight},
  author={Alberto Penas-Steinhardt and Luc{\'i}a Soledad Barcos and Fiorella Sabrina Belforte and Martha S de Sereday and Jorge O Vilari{\~n}o and Claudio Daniel Gonz{\'a}lez and Mar{\'i}a Teresa Mart{\'i}nez-Larrad and Mariana Lorena Tellechea and Manuel Serrano-R{\'i}os and E. Poskus and Gustavo Daniel Frechtel and Federico Coluccio Leskow},
  booktitle={PloS one},
  year={2012}
}

• Alberto Penas-Steinhardt, Lucía Soledad Barcos, +9 authors Federico Coluccio Leskow
• Published 2012 in PloS one
• DOI:10.1371/journal.pone.0050992

Subclinical low-grade systemic inflammation has been associated with obesity, insulin resistance and metabolic syndrome (MS). Recent studies have highlighted the role of gut microbiota in these disorders. The toll-like receptor 4 (TLR4) plays a key role in the innate immune response activation. We studied two polymorphisms (+3725G/C and 11350G/C) in the 3' untranslated region (3'UTR) of the TLR4 gene that may alter its expression and their association with metabolic disorders related to… CONTINUE READING

Save to Library

Create Alert

Cite

View Paper