Functional Characterization of TLR4 +3725 G/C Polymorphism and Association with Protection against Overweight

@inproceedings{PenasSteinhardt2012FunctionalCO,
  title={Functional Characterization of TLR4 +3725 G/C Polymorphism and Association with Protection against Overweight},
  author={Alberto Penas-Steinhardt and Luc{\'i}a Soledad Barcos and Fiorella Sabrina Belforte and Martha S de Sereday and Jorge O Vilari{\~n}o and Claudio Daniel Gonz{\'a}lez and Mar{\'i}a Teresa Mart{\'i}nez-Larrad and Mariana Lorena Tellechea and Manuel Serrano-R{\'i}os and E. Poskus and Gustavo Daniel Frechtel and Federico Coluccio Leskow},
  booktitle={PloS one},
  year={2012}
}
Subclinical low-grade systemic inflammation has been associated with obesity, insulin resistance and metabolic syndrome (MS). Recent studies have highlighted the role of gut microbiota in these disorders. The toll-like receptor 4 (TLR4) plays a key role in the innate immune response activation. We studied two polymorphisms (+3725G/C and 11350G/C) in the 3' untranslated region (3'UTR) of the TLR4 gene that may alter its expression and their association with metabolic disorders related to… CONTINUE READING
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The UCSC Genome Browser database: update 2010

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