Functional Characterization of Recombinant Rat Macrophage Inflammatory Protein-1α and mRNA Expression in Pulmonary Inflammation

@article{Shi1998FunctionalCO,
  title={Functional Characterization of Recombinant Rat Macrophage Inflammatory Protein-1α and mRNA Expression in Pulmonary Inflammation},
  author={Michael Ming Shi and Inn-Wen Chong and Nancy Carol Long and Jennifer A Love and John Godleski and Joseph D. Paulauskis},
  journal={Inflammation},
  year={1998},
  volume={22},
  pages={29-43}
}
Chemokines are important inflammatory mediators that function by activating and recruiting leukocytes to an inflamed tissue. We have recently cDNA cloned the rat chemokine macrophage inflammatory protein–1α (MIP-1α) (1). In the present study, we characterize the biological function of recombinant MIP-1α protein and describe expression of its mRNA both in vitro and in a rat model of lung inflammation. In vitro rat rMIP-1α protein was chemotactic for both polymorphonuclear leukocytes (PMNs) and… CONTINUE READING
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