Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation

@article{Hayashi2015FunctionalCO,
  title={Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation},
  author={Kenshi Hayashi and Tetsuo Konno and Hayato Tada and S Tani and Li Liu and Noboru Fujino and Atsushi Nohara and Akihiko Hodatsu and Toyonobu Tsuda and Yoshihiro Tanaka and Masa-aki Kawashiri and Hidekazu Ino and Naomasa Makita and Masakazu Yamagishi},
  journal={Circulation: Arrhythmia and Electrophysiology},
  year={2015},
  volume={8},
  pages={1095–1104}
}
Background—Few rare variants in atrial fibrillation (AF)–associated genes have been functionally characterized to identify a causal relationship between these variants and development of AF. We here sought to determine the clinical effect of rare variants in AF-associated genes in patients with lone AF and characterized these variants electrophysiologically and bioinformatically. Methods and Results—We screened all coding regions in 12 AF-associated genes in 90 patients with lone AF, with an… 
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