Functional Characteristics of Serotonin 5-HT2A and 5-HT2C Receptors in the Brain and the Expression of the 5-HT2A and 5-HT2C Receptor Genes in Aggressive and Non-Aggressive Rats

@article{Popova2010FunctionalCO,
  title={Functional Characteristics of Serotonin 5-HT2A and 5-HT2C Receptors in the Brain and the Expression of the 5-HT2A and 5-HT2C Receptor Genes in Aggressive and Non-Aggressive Rats},
  author={Nina K. Popova and Vladimir S. Naumenko and Rimma V. Kozhemyakina and Irena Z Plyusnina},
  journal={Neuroscience and Behavioral Physiology},
  year={2010},
  volume={40},
  pages={357-361}
}
The functional activity of serotonin 5-HT2A and 5-HT2C receptors and the expression of the genes encoding them were studied in Norway rats bred for 60 generations for the presence and absence of high levels of stress-evoked aggression to humans. There were no significant differences in the levels of 5-HT2A receptor mRNA in the midbrain, frontal cortex, and hippocampus and the extents of head twitching evoked by the 5-HT2A agonist DOI in rats with and without genetically determined high levels… CONTINUE READING

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