Functional Characterisation and Drug Target Validation of a Mitotic Kinesin-13 in Trypanosoma brucei

@inproceedings{Chan2010FunctionalCA,
  title={Functional Characterisation and Drug Target Validation of a Mitotic Kinesin-13 in Trypanosoma brucei},
  author={Kuan Yoow Chan and Keith R Matthews and Klaus Ersfeld},
  booktitle={PLoS pathogens},
  year={2010}
}
Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are now tested in clinical studies. Phylogenetic analyses have assigned five of the approximately fifty kinesin motor proteins coded by Trypanosoma brucei genome to the Kinesin-13 family. Kinesins of this family have unusual biochemical properties because they do not transport cargo… CONTINUE READING

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