Functional CNTF receptor alpha subunit restored by its recombinant in corneal endothelial cells in stored human donor corneas: connexin-43 upregulation.

Abstract

PURPOSE Ciliary neurotrophic factor (CNTF) is undergoing testing in human clinical trials to rescue degenerating retina, whereas studies show that the CNTF-binding alpha-subunit of the CNTF receptor (CNTFRalpha) is released from injured tissues. Here, the recombinant human (rh) CNTFRalpha was shown to restore functional CNTFRalpha in human corneal… (More)
DOI: 10.1167/iovs.08-2590

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@article{Koh2009FunctionalCR, title={Functional CNTF receptor alpha subunit restored by its recombinant in corneal endothelial cells in stored human donor corneas: connexin-43 upregulation.}, author={S W Koh and Jordan Celeste and C Y Paul Ku}, journal={Investigative ophthalmology & visual science}, year={2009}, volume={50 4}, pages={1801-7} }