Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity.

@article{Holmn2006FunctionalCR,
  title={Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity.},
  author={Nathalie Holm{\'e}n and Anna Lundgren and Samuel B Lundin and Ann-Marie H Bergin and Anna Rudin and Henrik Sj{\"o}vall and Lena Ohman},
  journal={Inflammatory bowel diseases},
  year={2006},
  volume={12 6},
  pages={
          447-56
        }
}
BACKGROUND Factors determining the extension and degree of inflammation in the colonic mucosa of patients with ulcerative colitis (UC) are largely unknown, but CD4+CD25high regulatory T cells (Tregs) have been implicated to play an important role in suppressing inflammation. Therefore, the aims of this study were to determine whether colonic Tregs have suppressive effects on colonic effector T cells in UC and to analyze the association between segmental colonic Treg distribution and disease… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 64 CITATIONS, ESTIMATED 63% COVERAGE

FILTER CITATIONS BY YEAR

2007
2019

CITATION STATISTICS

  • 1 Highly Influenced Citations