Cannabinoid CB2 receptors are expressed in glutamate neurons in the red nucleus and functionally modulate motor behavior in mice
- Biology, ChemistryNeuropharmacology
Presynaptic cannabinoid CB2 receptors modulate [3H]‐Glutamate release at subthalamo‐nigral terminals of the rat
The data showed that presynaptic CB2rs inhibit [3H]‐Glutamate release in subthalamo‐nigral terminals by P/Q‐channels modulation through the Giβγ subunit and suggested their participation in motor behavior.
CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity
- Biology, ChemistryJournal of psychopharmacology
Current understanding of CNR2 genomic structure, its polymorphic nature, subtype specificity, from mice to human subjects, and its variants that confer vulnerabilities to neuropsychiatric disorders beyond neuro-immuno-cannabinoid activity are summarized.
Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice
- Biology, ChemistryProceedings of the National Academy of Sciences
It is found that CB2R genes and receptors are expressed in midbrain DA neurons, and that activation of CB2Rs inhibits DA neuronal firing and i.v. cocaine self-administration, suggesting that brain CB 2Rs may constitute a new therapeutic target in medication development for treatment of a number of CNS disorders.
Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus
Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors
- BiologyProceedings of the National Academy of Sciences
It is shown that CB2Rs are located intracellularly in layer II/III pyramidal cells of the rodent medial prefrontal cortex and that their activation results in IP3R-dependent opening of Ca2+-activated Cl− channels and the description of this unique CB2R-mediated signaling pathway, controlling neuronal excitability, broadens the knowledge of the influence of the eCB system on brain function.
Cannabinoid receptor type 2 as a therapeutic target for Parkinson's disease
- Biology, Chemistry
Species Differences in Cannabinoid Receptor 2 and Receptor Responses to Cocaine Self-Administration in Mice and Rats
The discovery of functional cannabinoid receptors 2 (CB2Rs) in brain suggests a potential new therapeutic target for neurological and psychiatric disorders. However, recent findings in experimental…
CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory
- Biology, PsychologyNeural plasticity
The results suggest that CB2 cannabinoid receptors play diverse roles in regulating memory depending on memory types and/or brain areas, and CB2 receptor knockout mice displayed enhanced spatial working memory when tested in a Y-maze.
Progress in brain cannabinoid CB2 receptor research: From genes to behavior
- Biology, ChemistryNeuroscience & Biobehavioral Reviews
SHOWING 1-10 OF 67 REFERENCES
Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations
- BiologyThe European journal of neuroscience
It is concluded that activation of presynaptic CB1 receptors decreases Ca2+‐dependent GABA release, and thereby reduces the power of hippocampal network oscillations.
Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus
- Biology, ChemistryNeuroscience
Discovery of the Presence and Functional Expression of Cannabinoid CB2 Receptors in Brain
- BiologyAnnals of the New York Academy of Sciences
It is demonstrated that CB2 CBrs and their gene transcripts are widely distributed in the brain, contrary to the prevailing view that CB 2 CBrs are restricted to peripheral tissues and predominantly in immune cells.
Modulation of Network Oscillatory Activity and GABAergic Synaptic Transmission by CB1 Cannabinoid Receptors in the Rat Medial Entorhinal Cortex
- BiologyNeural plasticity
Data indicate that cannabinoid-mediated effects on inhibitory synaptic activity may be constitutively active in vitro, and that modulation of CB1R activation using inverse agonists unmasks complex effects of CBR function on network activity.
Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain
- BiologyBrain Research
Role of endogenous cannabinoids in synaptic signaling.
- Biology, ChemistryPhysiological reviews
The synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation, and the fine-grain anatomical distribution of the neuronal cannabinoid receptor CB1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release.
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
The transient suppression of GABA-mediated transmission that follows depolarization of hippocampal pyramidal neurons is mediated by retrograde signalling through release of endogenous cannabinoids, indicating that the function of endogenous cannabinoid released by depolarized hippocampal neurons might be to downregulate GABA release.
Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus
The subcellular distribution of CB2‐Rs in neuronal, glial, and endothelial cells in the rat hippocampus is shown using immunohistochemical electron microscopy to provide the first ultrastructural evidence that CB2-Rs are mainly postsynaptic in theRat hippocampus.
Identification of WIN55212‐3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor
- BiologyBritish journal of pharmacology
By monitoring receptor‐dependent G protein activation, it is demonstrated that WIN55212‐3 acts as a neutral antagonist at the human CB2 (hCB2) receptor, and may serve as a lead compound in further efforts to develop more potent and selective neutral CB2 receptor antagonists.
Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
- Biology, MedicineScience
These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors.