Functional Assessment of Four Types of Disintegrants and their Effect on the Spironolactone Release Properties


Spironolactone is a drug derived from sterols that exhibits an incomplete oral absorption due to its low water solubility and slow dissolution rate. In this study, formulations of spironolactone with four disintegrants named as croscarmellose sodium, crospovidone, sodium starch glycolate and microcrystalline cellulose II (MCCII) were conducted. The effect… (More)
DOI: 10.1208/s12249-012-9835-y


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