Functional Aspects of Neuroprotective Effects of New Salts and Compositions of Baclofen in the Convulsive Syndrome Caused by Electroshock

  title={Functional Aspects of Neuroprotective Effects of New Salts and Compositions of Baclofen in the Convulsive Syndrome Caused by Electroshock},
  author={Ivan N. Tyurenkov and L. E. Borodkina and V. V. Bagmetova},
  journal={Bulletin of Experimental Biology and Medicine},
New salts of baclofen (4-amino-3-(para-chlorophenyl)-butyric acid) and its compositions with organic carbonic acids (citric, succinic, malic, oxalic, nicotinic, glutamic acids and glycine) exhibited neuroprotective and anticonvulsive effects. They reduced the intensity of the convulsive syndrome and postconvulsive psychoneurological disorders in animals exposed to the maximum electroshock and electroconvulsive shock. Analogs of baclofen containing citrate and to a lesser extent those containing… 
Comparison of Nootropic and Neuroprotective Features of Aryl-Substituted Analogs of Gamma-Aminobutyric Acid
GABA analogs containing phenyl (phenibut) or para-chlorophenyl (baclofen) substituents demonstrated nootropic activity in a dose of 20 mg/kg and demonstrated neuroprotective properties on the maximum electroshock model: they shortened the duration of coma and shortened the period of spontaneous motor activity recovery.
Comparison of Neurotropic Effects of L-Glutamic Acid and Its New Derivative β-Phenylglutamic Acid Hydrochloride (RGPU-135, Glutarone)
Due to these neurotropic effects, β-phenylglutamic acid hydrochloride can be used as the basis for the development of drugs with antidepressant, anxiolytic, and neuroprotective actions.
Anticonvulsive profile of two GABAB receptor antagonists on acute seizure mice models
HEPP and, to a greater extent, Cl-H EPP provide anti-seizure protections in several acute seizure tests in mice at nontoxic doses, consistent with the action of these drugs on diverse molecular targets directly resulting from their MGBR antagonistic properties.
Baclofen Protects Primary Rat Retinal Ganglion Cells from Chemical Hypoxia-Induced Apoptosis Through the Akt and PERK Pathways
It is demonstrated that baclofen protects RGCs from CoCl2-induced apoptosis by increasing Akt activity and by suppressing the PERK pathway and CHOP activation.


Effects of baclofen on motor units paralysed by chronic cervical spinal cord injury.
Whether baclofen use and paralysis due to cervical spinal cord injury change the contractile properties of human thenar motor units more than paralysis alone is evaluated and its possible long-term effects on muscle rehabilitation are considered.
Cost-effectiveness Modeling of Intrathecal Baclofen Therapy Versus Other Interventions for Disabling Spasticity
The model simulations suggest that including ITB as a first option strategy in the management of function of severely impaired patients with disabling spasticity results in a higher success rate and a lower cost compared with conventional medical management without ITB.
Browne, Lockhart Clarke, Kesteven, Moxon, &c., the journal cannot fail to secure the support of the profession. With the exception of one or two articles, those which have already appeared are of an
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