Functional Aspects of Neuroprotective Effects of New Salts and Compositions of Baclofen in the Convulsive Syndrome Caused by Electroshock

@article{Tyurenkov2012FunctionalAO,
  title={Functional Aspects of Neuroprotective Effects of New Salts and Compositions of Baclofen in the Convulsive Syndrome Caused by Electroshock},
  author={I. N. Tyurenkov and L. E. Borodkina and V. V. Bagmetova},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2012},
  volume={153},
  pages={710-713}
}
New salts of baclofen (4-amino-3-(para-chlorophenyl)-butyric acid) and its compositions with organic carbonic acids (citric, succinic, malic, oxalic, nicotinic, glutamic acids and glycine) exhibited neuroprotective and anticonvulsive effects. They reduced the intensity of the convulsive syndrome and postconvulsive psychoneurological disorders in animals exposed to the maximum electroshock and electroconvulsive shock. Analogs of baclofen containing citrate and to a lesser extent those containing… Expand
Comparison of Nootropic and Neuroprotective Features of Aryl-Substituted Analogs of Gamma-Aminobutyric Acid
TLDR
GABA analogs containing phenyl (phenibut) or para-chlorophenyl (baclofen) substituents demonstrated nootropic activity in a dose of 20 mg/kg and demonstrated neuroprotective properties on the maximum electroshock model: they shortened the duration of coma and shortened the period of spontaneous motor activity recovery. Expand
Comparison of Neurotropic Effects of L-Glutamic Acid and Its New Derivative β-Phenylglutamic Acid Hydrochloride (RGPU-135, Glutarone)
TLDR
Due to these neurotropic effects, β-phenylglutamic acid hydrochloride can be used as the basis for the development of drugs with antidepressant, anxiolytic, and neuroprotective actions. Expand
Anticonvulsive profile of two GABAB receptor antagonists on acute seizure mice models
TLDR
HEPP and, to a greater extent, Cl-H EPP provide anti-seizure protections in several acute seizure tests in mice at nontoxic doses, consistent with the action of these drugs on diverse molecular targets directly resulting from their MGBR antagonistic properties. Expand
Baclofen Protects Primary Rat Retinal Ganglion Cells from Chemical Hypoxia-Induced Apoptosis Through the Akt and PERK Pathways
TLDR
It is demonstrated that baclofen protects RGCs from CoCl2-induced apoptosis by increasing Akt activity and by suppressing the PERK pathway and CHOP activation. Expand

References

SHOWING 1-10 OF 10 REFERENCES
Effects of baclofen on motor units paralysed by chronic cervical spinal cord injury.
TLDR
Whether baclofen use and paralysis due to cervical spinal cord injury change the contractile properties of human thenar motor units more than paralysis alone is evaluated and its possible long-term effects on muscle rehabilitation are considered. Expand
Cost-effectiveness Modeling of Intrathecal Baclofen Therapy Versus Other Interventions for Disabling Spasticity
TLDR
The model simulations suggest that including ITB as a first option strategy in the management of function of severely impaired patients with disabling spasticity results in a higher success rate and a lower cost compared with conventional medical management without ITB. Expand
Brain
Browne, Lockhart Clarke, Kesteven, Moxon, &c., the journal cannot fail to secure the support of the profession. With the exception of one or two articles, those which have already appeared are of anExpand
Khabriev, ed., Manual of Experimental (Preclinical) Studies of New Drugs [in Russian
  • Bulletin of Experimental Biology and Medicine,
  • 2012
Manual of Experimental (Preclinical) Studies of New Drugs
  • Manual of Experimental (Preclinical) Studies of New Drugs
  • 2005
Volgograd . Med. Akad
  • Volgograd . Med. Akad
  • 2004
Ibid
  • Ibid
  • 2003
Psychopharmacology and Biological Narcology
  • Psychopharmacology and Biological Narcology
  • 1982
Psychopharmacology and Biological Narcology [in Russian], St
  • Petersburg (2007), Vol. 7, Part 2, P.
  • 1982