Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process

@article{Treeck2009FunctionalAO,
  title={Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process},
  author={Moritz Treeck and Sonja Zacherl and Susann Herrmann and Ana L Cabrera and Maya Kono and Nicole S. Struck and Klemens Engelberg and Silvia Haase and Friedrich Frischknecht and Kota Miura and Tobias Spielmann and Tim Wolf Gilberger},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={467 - 475}
}
A key process in the lifecycle of the malaria parasite Plasmodium falciparum is the fast invasion of human erythrocytes. Entry into the host cell requires the apical membrane antigen 1 (AMA-1), a type I transmembrane protein located in the micronemes of the merozoite. Although AMA-1 is evolving into the leading blood-stage malaria vaccine candidate, its precise role in invasion is still unclear. We investigate AMA-1 function using live video microscopy in the absence and presence of an AMA-1… CONTINUE READING
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