Functional Analysis of Variance for Association Studies

  title={Functional Analysis of Variance for Association Studies},
  author={Olga A Vsevolozhskaya and Dmitri V. Zaykin and Mark C Greenwood and Changshuai Wei and Qing Lu and Zhi Wei},
  booktitle={PloS one},
While progress has been made in identifying common genetic variants associated with human diseases, for most of common complex diseases, the identified genetic variants only account for a small proportion of heritability. Challenges remain in finding additional unknown genetic variants predisposing to complex diseases. With the advance in next-generation sequencing technologies, sequencing studies have become commonplace in genetic research. The ongoing exome-sequencing and whole-genome… CONTINUE READING
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