Functional Analysis of Rhomboid Proteases during Toxoplasma Invasion

  title={Functional Analysis of Rhomboid Proteases during Toxoplasma Invasion},
  author={Bang Shen and Jeffrey S. Buguliskis and Tobie D. Lee and L. David Sibley},
Host cell invasion by Toxoplasma gondii and other apicomplexan parasites requires transmembrane adhesins that mediate binding to receptors on the substrate and host cell to facilitate motility and invasion. Rhomboid proteases (ROMs) are thought to cleave adhesins within their transmembrane segments, thus allowing the parasite to disengage from receptors and completely enter the host cell. To examine the specific roles of individual ROMs during invasion, we generated single, double, and triple… CONTINUE READING
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