Functional Analysis of Human Hematopoietic Stem Cell Gene Expression Using Zebrafish

  title={Functional Analysis of Human Hematopoietic Stem Cell Gene Expression Using Zebrafish},
  author={Craig E Eckfeldt and Eric M. Mendenhall and Catherine M. Flynn and Tzu-Fei Wang and Michael A. Pickart and Suzanne Grindle and Stephen C. Ekker and Catherine M. Verfaillie},
  journal={PLoS Biology},
  pages={35 - 71}
Although several reports have characterized the hematopoietic stem cell (HSC) transcriptome, the roles of HSC-specific genes in hematopoiesis remain elusive. To identify candidate regulators of HSC fate decisions, we compared the transcriptome of human umbilical cord blood and bone marrow (CD34+)(CD33-)(CD38-)Rho(lo)(c-kit+) cells, enriched for hematopoietic stem/progenitor cells with (CD34+)(CD33-)(CD38-)Rho(hi) cells, enriched in committed progenitors. We identified 277 differentially… CONTINUE READING


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