Functional Analysis of Hsp70 Inhibitors

Abstract

The molecular chaperones of the Hsp70 family have been recognized as targets for anti-cancer therapy. Since several paralogs of Hsp70 proteins exist in cytosol, endoplasmic reticulum and mitochondria, we investigated which isoform needs to be down-regulated for reducing viability of cancer cells. For two recently identified small molecule inhibitors, VER… (More)
DOI: 10.1371/journal.pone.0078443

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@inproceedings{Schlecht2013FunctionalAO, title={Functional Analysis of Hsp70 Inhibitors}, author={Rainer Schlecht and Sebastian Richard Scholz and Heike Dahmen and Ansgar Wegener and Christian Sirrenberg and Djordje Musil and Joerg Bomke and Hans-Michael Eggenweiler and Matthias P. Mayer and Bernd Bukau}, booktitle={PloS one}, year={2013} }