Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis

Abstract

Estrogen is believed to be pre-initiator in the risk of breast cancer. The BRCA1 is a tumor suppressor gene associated with breast and ovarian cancer risk. This report describes functional analysis of two BRCA1 missense mutations (Asp67Glu and Thr1051Ser) observed in the familial breast/ovarian cancer patients in Thailand. Levels of luciferase activity of… (More)
DOI: 10.3390/ijms10094187

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@inproceedings{Pongsavee2009FunctionalAO, title={Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis}, author={Malinee Pongsavee and Pimpicha Patmasiriwat and Grady F. Saunders}, booktitle={International journal of molecular sciences}, year={2009} }