Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways.

Abstract

S-adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. We report the design, synthesis, and evaluation of stable, functional AdoMet isosteres that are resistant to the primary contributors to AdoMet degradation (depurination, intramolecular cyclization… (More)
DOI: 10.1021/acschembio.6b00348

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Cite this paper

@article{Huber2016FunctionalAI, title={Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways.}, author={Tyler D Huber and Fengbin Wang and Shanteri Singh and Brooke Ronald Johnson and Jianjun Zhang and Manjula Sunkara and Steven G Van Lanen and Andrew J. Morris and George N. Phillips and Jon S Thorson}, journal={ACS chemical biology}, year={2016}, volume={11 9}, pages={2484-91} }