Functional α4-integrin: A newly identified pathway of neutrophil recruitment in critically ill septic patients

@article{Ibbotson2001FunctionalA,
  title={Functional α4-integrin: A newly identified pathway of neutrophil recruitment in critically ill septic patients},
  author={Geoffrey C. Ibbotson and Christopher Doig and Jaswinder Kaur and Varinder Gill and Lena L. Ostrovsky and Todd Fairhead and Paul Kubes},
  journal={Nature Medicine},
  year={2001},
  volume={7},
  pages={465-470}
}
Using a novel flow chamber assay system and whole blood, we show that leukocytes from septic individuals have a four-fold elevation of adhesion, but not rolling, on a P-selectin/β2-integrin substrate. Most leukocytes from septic patients (but not healthy controls) that bound vascular cell adhesion molecule 1 (VCAM-1) were neutrophils. All adhesion was inhibited with an antibody specific for the VCAM-1 ligand α4-integrin. The α4-integrin was present on neutrophils from septic patients but not on… CONTINUE READING