Functional α1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis

@article{Heijnen1996FunctionalR,
  title={Functional $\alpha$1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis},
  author={Cobi J. Heijnen and Charlotte Rouppe van der Voort and Nico M. Wulffraat and Janjaap van der Net and Wietse Kuis and Annemieke Kavelaars},
  journal={Journal of Neuroimmunology},
  year={1996},
  volume={71},
  pages={223-226}
}

The Reactivity of the Cardiovascular System and Immunomodulation by Catecholamines in Juvenile Chronic Arthritis

TLDR
The data show that patients with juvenile chronic arthritis have an altered function of the SNS associated with increased central noradrenergic outflow, presumably leading to increased vasoconstriction, resulting in a decreased response to an orthostatic stressor.

Disease Activity Related Catecholamine Response of Lymphocytes from Patients with Rheumatoid Arthritis

TLDR
The study demonstrates the intricate relationship between PBMC reactivity and catecholamine effects that is mediated via α‐ and β‐adrenergic receptors due to disease activity and suggests that the altered catechlamine response of PBMC from patients with RA may contribute to the pathogenic process of RA.

Beta2-adrenergic receptors mediate the differential effects of catecholamines on cytokine production of PBMC.

TLDR
Characteristics of beta2-adrenergic receptors (beta2R) on peripheral blood mononuclear cells (PBMC) and cytokine production after mitogenic stimulation and coincubation with catecholamines indicate that the density of beta1R on PBMC plays a role in mediating the differentialcatecholamine effects on cytokineProduction of PBMC.

Sympathetic neurotransmitters in joint inflammation.

Immunopathogenesis of Rheumatic Diseases in the Context of Neuroendocrine Interactions

TLDR
The decreased expression of β2‐adrenergic receptors (β2‐R) on lymphatic cells in rheumatic diseases like RA, together with an impaired influence of catecholamines on immune function in these patients, further underlines the concept of a dysfunction of the ANS in rHEumatic diseases.
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