Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy.

@article{Wolk1999FunctionalSA,
  title={Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy.},
  author={Robert M. Wolk and Stuart M. Cobbe and Martin N. Hicks and Kathleen A. Kane},
  journal={Pharmacology & therapeutics},
  year={1999},
  volume={84 2},
  pages={207-31}
}
The electrophysiological properties of the ventricular myocardium are extremely heterogeneous. There are intrinsic electrical differences between the myocytes from different regions of the heart (most notably between the epicardium, midmyocardium, and endocardium), which are the result of different contributions of ionic currents to the transmembrane action potential. Sources of local anisotropy include directional differences in the distribution of gap junctions between adjacent myocytes and… CONTINUE READING