Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi

@article{Laghari2018FunctionalSA,
  title={Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi},
  author={Zubair Ahmed Laghari and Shannan Chen and Li Li and Bei Huang and Zhen Gan and Ying Zhou and Hui Jun Huo and Jing Hou and Pin Nie},
  journal={Developmental and Comparative Immunology},
  year={2018},
  volume={84},
  pages={94–108}
}

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Identification of Two Subgroups of Type I IFNs in Perciforme Fish Large Yellow Croaker Larimichthys crocea Provides Novel Insights into Function and Regulation of Fish Type I IFNs

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This study identified two type I IFNs in the Perciforme fish large yellow croaker Larimichthys crocea and identified the recombinant IFNh, shown to be more potent to trigger a rapid induction of the antiviral genes MxA and protein kinase R than the IFNd, suggesting that they may play distinct roles in regulating early antiviral immunity.

Salmonids Have an Extraordinary Complex Type I IFN System: Characterization of the IFN Locus in Rainbow Trout Oncorhynchus mykiss Reveals Two Novel IFN Subgroups

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The results demonstrate that the IFN system of salmonids is far more complex than previously realized, and in-depth research is required to fully understand its regulation and function.

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Analysis of the regulatory elements in the IFN promoter region predicted several binding sites for key transcription factors that potentially play an important role in mediating IFN5 gene expression, which demonstrates that two subgroups are apparent within each of the 2C and 4C type I IFNs.

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