Function of von Willebrand factor in children with diarrhea-associated hemolytic-uremic syndrome (D+ HUS).

@article{Sutor2001FunctionOV,
  title={Function of von Willebrand factor in children with diarrhea-associated hemolytic-uremic syndrome (D+ HUS).},
  author={Anton Heinz Sutor and K. Bradford Thomas and Friederike Pr{\"u}fer and Andrea Grohmann and Matthias Brandis and L Bernd Zimmerhackl},
  journal={Seminars in thrombosis and hemostasis},
  year={2001},
  volume={27 3},
  pages={287-92}
}
Reports on von Willebrand factor (vWF) in hemolytic-uremic syndrome (HUS) are not unequivocal. Because of potential pathogenic implications, we examined the ability of vWF to bind to collagen in vitro, which reflects its function. Plasma vWF antigen (vWF:Ag) and collagen-binding activity (vWF:CBA) were measured by enzyme-linked immunosorbent assay in children with (1) diarrhea-associated (D+) HUS (n = 27), (2) chronic renal insufficiency (CRI) (n = 8), (3) gastroenteritis (GE) not associated… CONTINUE READING