Function of transcription cleavage factors GreA and GreB at a regulatory pause site.

@article{Marr2000FunctionOT,
  title={Function of transcription cleavage factors GreA and GreB at a regulatory pause site.},
  author={Michael T Marr and Jeffrey W. Roberts},
  journal={Molecular cell},
  year={2000},
  volume={6 6},
  pages={1275-85}
}
Gre proteins of prokaryotes, and SII proteins of eukaryotes and archaea, are transcription elongation factors that promote an endogenous transcript cleavage activity of RNA polymerases; this process promotes elongation through obstructive regions of DNA, including transcription pauses that act as sites of genetic regulation. We show that a regulatory pause in the early part of the late gene operon of bacteriophage lambda is subject to such cleavage and resynthesis. In cells lacking the cleavage… CONTINUE READING

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