Function of the mouse Mx1 protein is inhibited by overexpression of the PB2 protein of influenza virus.

@article{Strandn1993FunctionOT,
  title={Function of the mouse Mx1 protein is inhibited by overexpression of the PB2 protein of influenza virus.},
  author={Anne M. Strand{\'e}n and Peter Staeheli and Jovan Pavlovic},
  journal={Virology},
  year={1993},
  volume={197 2},
  pages={642-51}
}
The interferon-induced murine Mx1 protein possesses an intrinsic antiviral activity with selectivity for influenza viruses. Mx1 accumulates in the nucleus and inhibits the replication of influenza virus at the level of primary transcription. Simultaneous overexpression of the three influenza virus polymerase subunits via recombinant vaccinia virus vectors can titrate out the inhibitory action of Mx1 as determined by the amplification of a transfected recombinant viral reporter gene. A low… CONTINUE READING

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