Function of the blood-brain barrier and restriction of drug delivery to invasive glioma cells: findings in an orthotopic rat xenograft model of glioma.

@article{Agarwal2013FunctionOT,
  title={Function of the blood-brain barrier and restriction of drug delivery to invasive glioma cells: findings in an orthotopic rat xenograft model of glioma.},
  author={Sagar Agarwal and Pooja Manchanda and Michael A. Vogelbaum and John R. Ohlfest and William F Elmquist},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2013},
  volume={41 1},
  pages={33-9}
}
Despite aggressive treatment with radiation and chemotherapy, recurrence of glioblastoma multiforme (GBM) is inevitable. The objective of this study was to show that the blood-brain barrier (BBB), through a combination of tight junctions and active efflux transporters in the brain microvasculature, can significantly restrict delivery of molecularly targeted agents to invasive glioma cells. Transgenic mice lacking P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) were used to… CONTINUE READING

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