Function of the Shaw Potassium Channel within the Drosophila Circadian Clock

@article{Hodge2008FunctionOT,
  title={Function of the Shaw Potassium Channel within the Drosophila Circadian Clock},
  author={James J. L. Hodge and Ralf Stanewsky},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={111 - 147}
}
BACKGROUND In addition to the molecular feedback loops, electrical activity has been shown to be important for the function of networks of clock neurons in generating rhythmic behavior. Most studies have used over-expression of foreign channels or pharmacological manipulations that alter membrane excitability. In order to determine the cellular mechanisms that regulate resting membrane potential (RMP) in the native clock of Drosophila we modulated the function of Shaw, a widely expressed… CONTINUE READING

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