Function of the M1 π-helix in endplate receptor activation and desensitization.


KEY POINTS A conserved proline in M1 causes a kink between α and π helical segments. The kink is under greater tension in the resting versus active conformation. The kink and the agonist do not interact directly. The π-helix separates the gating functions of the extracellular and transmembrane domains. Mutations of the conserved proline and propofol… (More)
DOI: 10.1113/JP270223