Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity.

@article{Tewari2002FunctionOR,
  title={Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity.},
  author={Rita Tewari and Roberta Spaccapelo and Francesco Bistoni and Anthony A. Holder and Andrea Crisanti},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 49},
  pages={47613-8}
}
The circumsporozoite protein of Plasmodium falciparum contains two conserved motifs (regions I and II) that have been proposed to interact with mosquito and vertebrate host molecules in the process of sporozoite invasion of salivary glands and hepatocytes, respectively. To study the function of this protein we have replaced the endogenous circumsporozoite protein gene of Plasmodium berghei with that of P. falciparum and with versions lacking either region I or region II. We show here that P… CONTINUE READING

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