Function of pulmonary M2 muscarinic receptors in antigen-challenged guinea pigs is restored by heparin and poly-L-glutamate.

@article{Fryer1992FunctionOP,
  title={Function of pulmonary M2 muscarinic receptors in antigen-challenged guinea pigs is restored by heparin and poly-L-glutamate.},
  author={Allison D Fryer and David B Jacoby},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 6},
  pages={2292-8}
}
The effect of heparin and poly-L-glutamate on the function of inhibitory M2 muscarinic autoreceptors on parasympathetic nerves in the lung was tested in antigen-challenged guinea pigs. After antigen challenge, M2 receptor function is decreased, thus increasing release of acetylcholine from the vagus and potentiating vagally induced bronchoconstriction. Guinea pigs were anesthetized, tracheostomized, vagotomized, paralyzed, and ventilated. Electrical stimulation of the vagi caused… CONTINUE READING

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Changes in neuronal control of airway smooth muscle after exposure to ozone

  • K. Ishida, L. J. Kelly, R. J. Thomson, L. L. Beattie
  • 1991

Loss of neuronal M 2 muscarinic autoreceptor function in antigen challenged guinea - pigs

  • A. D. Fryer, J. Maclagan
  • J . Appl . Physiol .
  • 1991

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