Function of proteoglycans in the extracellular matrix.

  title={Function of proteoglycans in the extracellular matrix.},
  author={Masaki Yanagishita},
  journal={Acta pathologica japonica},
  volume={43 6},
Proteoglycans are glycosylated proteins which have covalently attached highly anionic glycosaminoglycans. Many forms of proteoglycans are present in virtually all extracellular matrices of connective tissues. The major biological function of proteoglycans derives from the physicochemical characteristics of the glycosaminoglycan component of the molecule, which provides hydration and swelling pressure to the tissue enabling it to withstand compressional forces. This function is best illustrated… CONTINUE READING