Function of local circuits in the hippocampal dentate gyrus-CA3 system

  title={Function of local circuits in the hippocampal dentate gyrus-CA3 system},
  author={Yuta Senzai},
  journal={Neuroscience Research},
  • Y. Senzai
  • Published 1 March 2019
  • Biology
  • Neuroscience Research

Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories

The cells and circuits of the dentate gyrus are examined, and evidence indicating that this brain region has multiple mnemonic functions is discussed, to explore mechanistic links between the cellular and network properties of, and the computations performed by, the DG.

Theta phase specific modulation of hippocampal memory neurons

Results provide a causal link between phase-specific activation of engram cells and the behavioral expression of memory and show that stimulating engram neurons at the trough of theta is more effective in eliciting behavioral recall than either fixed frequency stimulation or stimulation at the peak of theTA.

Disruption of circadian timing increases synaptic inhibition and reduces cholinergic responsiveness in the dentate gyrus

Findings show that loss of circadian timing is accompanied by greater tonic inhibition, and increased synaptic inhibition in response to muscarinic receptor activation in dentate granule cells, which might explain the spatial memory deficits previously observed in circadian‐arrhythmic hamsters.

Molecular and Cellular Mechanisms Underlying Somatostatin-Based Signaling in Two Model Neural Networks, the Retina and the Hippocampus

This work analyzes the somatostatinergic system in two regions of the central nervous system: the retina and the hippocampus, and identifies common motifs in the action of som atostatin that may explain its involvement in such diverse circuitries.

Locus coeruleus in memory formation and Alzheimer's disease

The multifaceted role of the LC in memory and general task performance and the close correlation of LC degeneration with neurodegenerative disease progression together implicate it as a target for new clinical assessment tools.

Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective

It is proposed that through its computational influences AHN is pivotal in shaping adaption to environmental demands, underlying its role in stress response, and its effects result in gating downstream brain areas with more accurate and contextualized information, enabling the different dimensions of the stress response to be more appropriately set with specific contexts.

The fibro‐ and cyto‐architecture demarcating the border between the dentate gyrus and CA3 in sheep (Ovis aries) and domestic pig (Sus scrofa domesticus)

A light microscopic investigation based on Golgi‐impregnated and Timm–thionin‐stained sections of the Artiodactyla sheep and domestic pig shows that the border between the dentate gyrus and the CA3 end can be more accurately localized by the mossy fiber system than by cyto‐architecture alone.

AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function

The results suggest that knocking down TRPC6 in the DG have a disadvantageous effect on cognitive processes.



The CA3 "backprojection" to the dentate gyrus.

Computational analysis of the role of the hippocampus in memory

The authors draw together the results of a series of detailed computational studies and show how they are contributing to the development of a theory of hippocampal function by producing a computational theory of how it operates, based on neuroanatomical and neurophysiological information about the different neuronal systems contained within the hippocampus.

Computational constraints suggest the need for two distinct input systems to the hippocampal CA3 network

The CA3 network in the hippocampus may operate as an autoassociator, in which declarative memories, known to be dependent on hippocampal processing, could be stored, and subsequently retrieved, using

Cytoarchitectonic and Dynamic Origins of Giant Positive Local Field Potentials in the Dentate Gyrus

It is concluded that the activation of layered structures may establish sharply delimited spatial domains where synaptic currents from one or another input appear to be segregated according to the topology of afferent pathways and the cytoarchitectonic features of the target population.

The role of the dentate gyrus, CA3a,b, and CA3c for detecting spatial and environmental novelty

It is suggested that the dentate gyrus (DG) is critical for spatial information processing and CA3 is a heterogeneous structure, with CA3c lesioned animals showing greater spatial processing deficits than CA3a,bLesioned animals.

Spatial Firing Correlates of Physiologically Distinct Cell Types of the Rat Dentate Gyrus

It is reported here that cells below the granule layer show spatially selective firing that consists of multiple subfields, and it is hypothesized that cells with multiple fields might be cells of the hilus or newborn granule cells, the first demonstration, based on physiological criteria, that single- and multiple-field cells constitute at least two distinct cell classes in the DG.

Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus

These results imply a dual mechanism for pattern separation in which signals from the entorhinal cortex can be decorrelated both by changes in coincidence patterns in the dentate gyrus and by recruitment of nonoverlapping cell assemblies in CA3.

A golgi study of cell types in the hilar region of the hippocampus in the rat

  • D. Amaral
  • Biology
    The Journal of comparative neurology
  • 1978
The results of the present study do not support the proposition that the deep hilar region is an extension of the pyramidal layer of the hippocampus as suggested by Lorente de Nó ('34), and thus CA4 is a misnomer.