Function of local circuits in the hippocampal dentate gyrus-CA3 system

  title={Function of local circuits in the hippocampal dentate gyrus-CA3 system},
  author={Yuta Senzai},
  journal={Neuroscience Research},
  • Y. Senzai
  • Published 1 March 2019
  • Biology
  • Neuroscience Research

Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories

The cells and circuits of the dentate gyrus are examined, and evidence indicating that this brain region has multiple mnemonic functions is discussed, to explore mechanistic links between the cellular and network properties of, and the computations performed by, the DG.

Theta phase specific modulation of hippocampal memory neurons

Results provide a causal link between phase-specific activation of engram cells and the behavioral expression of memory and show that stimulating engram neurons at the trough of theta is more effective in eliciting behavioral recall than either fixed frequency stimulation or stimulation at the peak of theTA.

Involvement of the Hypothalamic Nuclei in Forming Object–Place Associations in Neurons of Hippocampal Field CA2 (a hypothetical mechanism)

  • I. Silkis
  • Biology
    Neuroscience and Behavioral Physiology
  • 2021
A possible mechanism for the formation of representations of object–place associations in hippocampal neurons based on plastic rearrangements of the efficiency of synaptic transmission, which depends

Molecular and Cellular Mechanisms Underlying Somatostatin-Based Signaling in Two Model Neural Networks, the Retina and the Hippocampus

This work analyzes the somatostatinergic system in two regions of the central nervous system: the retina and the hippocampus, and identifies common motifs in the action of som atostatin that may explain its involvement in such diverse circuitries.

Locus coeruleus in memory formation and Alzheimer's disease

The multifaceted role of the LC in memory and general task performance and the close correlation of LC degeneration with neurodegenerative disease progression together implicate it as a target for new clinical assessment tools.

Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective

It is proposed that through its computational influences AHN is pivotal in shaping adaption to environmental demands, underlying its role in stress response, and its effects result in gating downstream brain areas with more accurate and contextualized information, enabling the different dimensions of the stress response to be more appropriately set with specific contexts.

AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function

The results suggest that knocking down TRPC6 in the DG have a disadvantageous effect on cognitive processes.

Molecular and subregion mechanisms of episodic memory phenotypes in temporal lobe epilepsy

Results suggest memory impairment in temporal lobe epilepsy with hippocampal sclerosis is associated with molecular alterations within temporal lobe subregions that are independent from hippocampal cell loss, demographic variables and disease characteristics.



The CA3 "backprojection" to the dentate gyrus.

Computational constraints suggest the need for two distinct input systems to the hippocampal CA3 network

The CA3 network in the hippocampus may operate as an autoassociator, in which declarative memories, known to be dependent on hippocampal processing, could be stored, and subsequently retrieved, using

The role of the dentate gyrus, CA3a,b, and CA3c for detecting spatial and environmental novelty

It is suggested that the dentate gyrus (DG) is critical for spatial information processing and CA3 is a heterogeneous structure, with CA3c lesioned animals showing greater spatial processing deficits than CA3a,bLesioned animals.

Spatial Firing Correlates of Physiologically Distinct Cell Types of the Rat Dentate Gyrus

It is reported here that cells below the granule layer show spatially selective firing that consists of multiple subfields, and it is hypothesized that cells with multiple fields might be cells of the hilus or newborn granule cells, the first demonstration, based on physiological criteria, that single- and multiple-field cells constitute at least two distinct cell classes in the DG.

Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus

These results imply a dual mechanism for pattern separation in which signals from the entorhinal cortex can be decorrelated both by changes in coincidence patterns in the dentate gyrus and by recruitment of nonoverlapping cell assemblies in CA3.

The mechanisms for pattern completion and pattern separation in the hippocampus

  • E. Rolls
  • Biology
    Front. Syst. Neurosci.
  • 2013
The mechanisms for pattern completion and pattern separation are described in the context of a theory of hippocampal function in which the hippocampal CA3 system operates as a single attractor or

A golgi study of cell types in the hilar region of the hippocampus in the rat

  • D. Amaral
  • Biology
    The Journal of comparative neurology
  • 1978
The results of the present study do not support the proposition that the deep hilar region is an extension of the pyramidal layer of the hippocampus as suggested by Lorente de Nó ('34), and thus CA4 is a misnomer.

Subdivisions in the Multiple GABAergic Innervation of Granule Cells in the Dentate Gyrus of the Rat Hippocampus

It is demonstrated that granule cells receive inputs from the local circuit axons of at least five distinct types of dentate neuron terminating in mutually exclusive domains of the cell's surface in four out of five cases.