Function of human α3β4α5 nicotinic acetylcholine receptors is reduced by the α5(D398N) variant.

@article{George2012FunctionOH,
  title={Function of human α3β4α5 nicotinic acetylcholine receptors is reduced by the α5(D398N) variant.},
  author={A. A. Paul George and Linda M Lucero and Mohamad Imad Damaj and Ronald J. Lukas and Xiangning Chen and Paul Whiteaker},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 30},
  pages={25151-62}
}
Genome-wide studies have strongly associated a non-synonymous polymorphism (rs16969968) that changes the 398th amino acid in the nAChR α5 subunit from aspartic acid to asparagine (D398N), with greater risk for increased nicotine consumption. We have used a pentameric concatemer approach to express defined and consistent populations of α3β4α5 nAChR in Xenopus oocytes. α5(Asn-398; risk) variant incorporation reduces ACh-evoked function compared with inclusion of the common α5(Asp-398) variant… CONTINUE READING

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Functional properties of concatenated 3 4 and 3 4 5 nicotinic receptors

  • A. A. George, M. Bhakta, L. M. Lucero, R. J. Lukas, P. Whiteaker
  • Soc. Neurosci. Abst
  • 2011
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