Function of hepatic triglyceride lipase in lipoprotein metabolism.

  title={Function of hepatic triglyceride lipase in lipoprotein metabolism.},
  author={Josh Grosser and Otto Schrecker and Heiner Greten},
  journal={Journal of lipid research},
  volume={22 3},
Rat hepatic triglyceride lipase (H-TGL) was purified from liver tissue extracts by affinity chromatography on Sepharose 4B with covalently linked heparin. The purified rat H-TGL exhibited the properties previously described for this enzyme. Enzyme protein was injected into rabbits for anti-H-TGL antibody production. Antirat-H-TGL did not react against rat lipoprotein lipase (LPL) but inhibited H-TGL-activity both in vitro and in vivo greater than 90%. These antibodies were injected into rats… CONTINUE READING


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