Function of extracellular vesicle-associated miRNAs in metastasis

@article{Dhondt2016FunctionOE,
  title={Function of extracellular vesicle-associated miRNAs in metastasis},
  author={Bert Dhondt and Quentin Rousseau and Olivier De Wever and An Hendrix},
  journal={Cell and Tissue Research},
  year={2016},
  volume={365},
  pages={621-641}
}
Extracellular RNA (exRNA) is functionally transferrable from donor to recipient cells and is protected from RNAses by electrostatic interactions with proteins or by membrane encapsulation. In addition to bioactive RNA, extracellular vesicles (EVs) contain intraluminal and membrane-associated proteins. The cellular context and fitness affect the composition of EVs and thus the outcome of the communication between the EV-producer and recipient cells. Adaptive communication through EVs is… Expand
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31 Citations
Background Citations
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Methods Citations
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31 Citations

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Citation Type

Future directions of extracellular vesicle-associated miRNAs in metastasis.
TLDR
A profound review of Dhondt et al., 2016 provides a wide view of EV miRNAs involved in various steps of the metastasis process to illustrate how the cancer cell interaction with the near and long distance microenvironment allows metastasis. Expand
Extracellular vesicles-mediated noncoding RNAs transfer in cancer
TLDR
Given their stability and abundance in serum, EV-associated ncRNAs can act as new diagnostic biomarkers and new therapeutic targets for cancer. Expand
Extracellular Vesicles in Cancer
Extracellular vesicles (EVs) represent a generic term for all the secreted vesicles, which include exosomes, microvesicles, and apoptotic bodies. EVs are key partners in the intercellular… Expand
The isolation of morphologically intact and biologically active extracellular vesicles from the secretome of cancer-associated adipose tissue
TLDR
dUC-ODG purifies EVs from conditioned medium of cancer-associated adipose tissue, and these EVs are morphologically intact and biologically active. Expand
Biological Activities of Secretory RNases: Focus on Their Oligomerization to Design Antitumor Drugs
TLDR
The results concerning the biological features of many RNases reported in the literature are described and discussed in this review and are offered with the perspective to suggest possible efficacious therapeutic applications for RNases oligomeric derivatives that could contemporarily lack, or strongly reduce, immunogenicity and other undesired side-effects. Expand
microRNAs as players and signals in the metastatic cascade: Implications for the development of novel anti-metastatic therapies.
TLDR
Preclinical research carried out in tumor experimental models, using both miRNA replacement and miRNA inhibitory approaches, is encouraging towards translating miRNA-based strategies into human cancer therapy, based on the observed therapeutic activity in the absence of main toxicity. Expand
Circular RNAs and exosomes in cancer: a mysterious connection
TLDR
The characteristics of circRNAs are summarized, especially its main functions, and exo-circRNAs may be a novel pathway for cancer diagnosis and targeted therapy. Expand
Roles of exosomes in the normal and diseased eye
TLDR
Current knowledge of exosome function in the visual system is reviewed in the context of larger bodies of data from other fields, in both health and disease, to identify areas of opportunity for future research studies. Expand
Isolation and Identification of miRNAs in exosomes derived from serum of colon cancer patients
TLDR
This study proves that commercial kits for exosome separation are more convenient and time-saving and that mass spectrometry is capable of identifying the miRNAs in exosomes and demonstrates that the exosomal miRNA-21 expression is associated with the early diagnosis of colon cancer. Expand
Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases
TLDR
The potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application are analyzed. Expand
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