Function of extracellular vesicle-associated miRNAs in metastasis

  title={Function of extracellular vesicle-associated miRNAs in metastasis},
  author={Bert Dhondt and Quentin Rousseau and Olivier De Wever and An Hendrix},
  journal={Cell and Tissue Research},
Extracellular RNA (exRNA) is functionally transferrable from donor to recipient cells and is protected from RNAses by electrostatic interactions with proteins or by membrane encapsulation. In addition to bioactive RNA, extracellular vesicles (EVs) contain intraluminal and membrane-associated proteins. The cellular context and fitness affect the composition of EVs and thus the outcome of the communication between the EV-producer and recipient cells. Adaptive communication through EVs is… 

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