Function of extracellular vesicle-associated miRNAs in metastasis

@article{Dhondt2016FunctionOE,
  title={Function of extracellular vesicle-associated miRNAs in metastasis},
  author={Bert Dhondt and Quentin Rousseau and Olivier De Wever and An Hendrix},
  journal={Cell and Tissue Research},
  year={2016},
  volume={365},
  pages={621-641}
}
Extracellular RNA (exRNA) is functionally transferrable from donor to recipient cells and is protected from RNAses by electrostatic interactions with proteins or by membrane encapsulation. In addition to bioactive RNA, extracellular vesicles (EVs) contain intraluminal and membrane-associated proteins. The cellular context and fitness affect the composition of EVs and thus the outcome of the communication between the EV-producer and recipient cells. Adaptive communication through EVs is… Expand
Future directions of extracellular vesicle-associated miRNAs in metastasis.
TLDR
A profound review of Dhondt et al., 2016 provides a wide view of EV miRNAs involved in various steps of the metastasis process to illustrate how the cancer cell interaction with the near and long distance microenvironment allows metastasis. Expand
Extracellular vesicles-mediated noncoding RNAs transfer in cancer
TLDR
Given their stability and abundance in serum, EV-associated ncRNAs can act as new diagnostic biomarkers and new therapeutic targets for cancer. Expand
Extracellular Vesicles in Cancer
Extracellular vesicles (EVs) represent a generic term for all the secreted vesicles, which include exosomes, microvesicles, and apoptotic bodies. EVs are key partners in the intercellularExpand
The isolation of morphologically intact and biologically active extracellular vesicles from the secretome of cancer-associated adipose tissue
TLDR
dUC-ODG purifies EVs from conditioned medium of cancer-associated adipose tissue, and these EVs are morphologically intact and biologically active. Expand
Biological Activities of Secretory RNases: Focus on Their Oligomerization to Design Antitumor Drugs
TLDR
The results concerning the biological features of many RNases reported in the literature are described and discussed in this review and are offered with the perspective to suggest possible efficacious therapeutic applications for RNases oligomeric derivatives that could contemporarily lack, or strongly reduce, immunogenicity and other undesired side-effects. Expand
microRNAs as players and signals in the metastatic cascade: Implications for the development of novel anti-metastatic therapies.
TLDR
Preclinical research carried out in tumor experimental models, using both miRNA replacement and miRNA inhibitory approaches, is encouraging towards translating miRNA-based strategies into human cancer therapy, based on the observed therapeutic activity in the absence of main toxicity. Expand
Circular RNAs and exosomes in cancer: a mysterious connection
TLDR
The characteristics of circRNAs are summarized, especially its main functions, and exo-circRNAs may be a novel pathway for cancer diagnosis and targeted therapy. Expand
Roles of exosomes in the normal and diseased eye
TLDR
Current knowledge of exosome function in the visual system is reviewed in the context of larger bodies of data from other fields, in both health and disease, to identify areas of opportunity for future research studies. Expand
Isolation and Identification of miRNAs in exosomes derived from serum of colon cancer patients
TLDR
This study proves that commercial kits for exosome separation are more convenient and time-saving and that mass spectrometry is capable of identifying the miRNAs in exosomes and demonstrates that the exosomal miRNA-21 expression is associated with the early diagnosis of colon cancer. Expand
Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases
TLDR
The potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application are analyzed. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 135 REFERENCES
Sorting it out: regulation of exosome loading.
TLDR
How the cellular context affects the composition of exosomes, and thus the outcome of the communication between the exosome-producer and recipient cells, is discussed, with particular focus on the Communication between tumor cells and with cells of the tumor microenvironment. Expand
Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line
TLDR
The enrichment of let-7 miRNA family in the extracellular fractions, particularly, in the exosomes from AZ-P7a cells may reflect their oncogenic characteristics including tumorigenesis and metastasis. Expand
Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis*
TLDR
It is demonstrated that the neutral sphyngomyelinase 2 (nSMase2) regulates exosomal microRNA (miRNA) secretion and promotes angiogenesis within the tumor microenvironment as well as metastasis, suggesting that the horizontal transfer of exosome miRNAs from cancer cells can dictate the microenviromental niche for the benefit of the cancer cell. Expand
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TLDR
It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA). Expand
Intercellular nanovesicle‐mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth
TLDR
It is shown that HCC cell‐derived exosomes can modulate TAK1 expression and associated signaling and enhance transformed cell growth in recipient cells, identifying a unique intercellular mechanism that could potentially contribute to local spread, intrahepatic metastases, or multifocal growth in HCC. Expand
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
TLDR
Identification of extracellular Ago2–miRNA complexes in plasma raises the possibility that cells release a functional miRNA-induced silencing complex into the circulation, and reveals two populations of circulating miRNAs and suggest that circulating Ago2 complexes are a mechanism responsible for the stability of plasma mi RNAs. Expand
Exosomal tumor microRNA modulates premetastatic organ cells.
TLDR
Fitting the demands of metastasizing tumor cells, transferred exosomal miRNA mostly affected proteases, adhesion molecules, chemokine ligands, cell cycle- and angiogenesis-promoting genes, and genes engaged in oxidative stress response. Expand
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
TLDR
It is shown that tumor-secreted miR-21 andmiR-29a also can function by another mechanism, by binding as ligands to receptors of the Toll-like receptor (TLR) family, murine TLR7 and human TLR8, in immune cells, triggering a TLR-mediated prometastatic inflammatory response that ultimately may lead to tumor growth and metastasis. Expand
Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200
TLDR
The data obtained in this study are consistent with the hypothesis that the releases of exosomes varies significantly between ovarian cancer cell lines and correlates with their invasive potential. Expand
Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties.
TLDR
It is suggested that exosome-mediated secretion of tumor-suppressor miRNA is selected during tumor progression as a mechanism to coordinate activation of a metastatic cascade. Expand
...
1
2
3
4
5
...