Function of dynein and dynactin in herpes simplex virus capsid transport.

  title={Function of dynein and dynactin in herpes simplex virus capsid transport.},
  author={Katinka D{\"o}hner and Andr{\'e} Wolfstein and Ute Prank and Christophe J. Echeverri and Denis Dujardin and Richard B Vallee and Beate Sodeik},
  journal={Molecular biology of the cell},
  volume={13 8},
After fusion of the viral envelope with the plasma membrane, herpes simplex virus type 1 (HSV1) capsids are transported along microtubules (MTs) from the cell periphery to the nucleus. The motor ATPase cytoplasmic dynein and its multisubunit cofactor dynactin mediate most transport processes directed toward the minus-ends of MTs. Immunofluorescence microscopy experiments demonstrated that HSV1 capsids colocalized with cytoplasmic dynein and dynactin. We blocked the function of dynein by… CONTINUE READING


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Herpes simplex viruses and their replication

  • B. Roizman, D. M. Knipe
  • Fundamental Virology, 4th ed.,
  • 2001
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