Function of cGMP-dependent protein kinases in the nervous system.

  title={Function of cGMP-dependent protein kinases in the nervous system.},
  author={Robert Feil and Franz Hofmann and Thomas Kleppisch},
  journal={Reviews in the neurosciences},
  volume={16 1},
The second messenger cyclic guanosine-3',5'-monophosphate (cGMP) mediates many effects of nitric oxide in the nervous system. cGMP may act through various intracellular receptors, among them a family of serine/threonine kinases, the cGMP-dependent protein kinases (cGKs). Hitherto, three mammalian cGKs have been identified: cGKIalpha, cGKIbeta and cGKII. Discrete functions of cGKI and cGKII are determined by their distinct expression patterns and targeting to specific substrates. This review… CONTINUE READING


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