Function of an axonal chemoattractant modulated by metalloprotease activity.

  title={Function of an axonal chemoattractant modulated by metalloprotease activity.},
  author={Michael J Galko and Marc Tessier-Lavigne},
  volume={289 5483},
The axonal chemoattractant netrin-1 guides spinal commissural axons by activating its receptor DCC (Deleted in Colorectal Cancer). We have found that chemical inhibitors of metalloproteases potentiate netrin-mediated axon outgrowth in vitro. We have also found that DCC is a substrate for metalloprotease-dependent ectodomain shedding, and that the inhibitors block proteolytic processing of DCC and cause an increase in DCC protein levels on axons within spinal cord explants. Thus, potentiation of… CONTINUE READING


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