Function of a minus-end-directed kinesin-like motor protein in mammalian cells.

@article{Matuliene1999FunctionOA,
  title={Function of a minus-end-directed kinesin-like motor protein in mammalian cells.},
  author={Jurgita Matuliene and Russell Essner and Jiyoon Ryu and Yukihisa Hamaguchi and Peter W. Baas and Tokuko Haraguchi and Yasushi Hiraoka and Ryoko Kuriyama},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 22)},
  pages={
          4041-50
        }
}
CHO2 is a mammalian minus-end-directed kinesin-like motor protein present in interphase centrosomes/nuclei and mitotic spindle fibers/poles. Expression of HA- or GFP-tagged subfragments in transfected CHO cells revealed the presence of the nuclear localization site at the N-terminal tail. This domain becomes associated with spindle fibers during mitosis, indicating that the tail is capable of interaction with microtubules in vivo. While the central stalk diffusely distributes in the entire… CONTINUE READING
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