Function of a conserved checkpoint recruitment domain in ATRIP proteins.

  title={Function of a conserved checkpoint recruitment domain in ATRIP proteins.},
  author={Heather L. Ball and Mark Ehrhardt and Daniel A. Mordes and Gloria G. Glick and Walter J Chazin and David Cortez},
  journal={Molecular and cellular biology},
  volume={27 9},
The ATR (ATM and Rad3-related) kinase is essential to maintain genomic integrity. ATR is recruited to DNA lesions in part through its association with ATR-interacting protein (ATRIP), which in turn interacts with the single-stranded DNA binding protein RPA (replication protein A). In this study, a conserved checkpoint protein recruitment domain (CRD) in ATRIP orthologs was identified by biochemical mapping of the RPA binding site in combination with nuclear magnetic resonance, mutagenesis, and… CONTINUE READING


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