Function of Rta is essential for lytic replication of murine gammaherpesvirus 68.

@article{Wu2001FunctionOR,
  title={Function of Rta is essential for lytic replication of murine gammaherpesvirus 68.},
  author={Ting-Ting Wu and Leming Tong and Tammy M. Rickabaugh and Stephanie Speck and Ren Sun},
  journal={Journal of virology},
  year={2001},
  volume={75 19},
  pages={9262-73}
}
Rta, encoded primarily by open reading frame 50, is well conserved among gammaherpesviruses. It has been shown that the Rta proteins of Epstein Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV, or HHV-8), and murine gammaherpesvirus 68 (MHV-68; also referred to as gamma HV68) play an important role in viral reactivation from latency. However, the role of Rta during productive de novo infection has not been characterized in gammaherpesviruses. Since there are cell lines that can… CONTINUE READING

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