Function of RasGRP3 in the formation and progression of human breast cancer

@inproceedings{Nagy2013FunctionOR,
  title={Function of RasGRP3 in the formation and progression of human breast cancer},
  author={Zsuzsanna S. Nagy and Ilona Sz{\'e}kely Kov{\'a}cs and Mikl{\'o}s T{\"o}r{\"o}k and Dezső T{\'o}th and Gy{\"o}rgy Vereb and Krisztina Buzas and Istv{\'a}n Juh{\'a}sz and Peter M. Blumberg and Tam{\'a}s B{\'i}r{\'o} and Gabriella Czifra},
  booktitle={Molecular Cancer},
  year={2013}
}
Ras guanine nucleotide exchange factors (RasGEFs) mediate the activation of the Ras signaling pathway that is over activated in many human cancers. The RasGRP3, an activator of H-Ras and R-Ras protein exerts oncogenic effects and the overexpression of the protein is observed in numerous malignant cancer types. Here, we investigated the putative alteration of expression and potential function of RasGRP3 in the formation and progression of human breast cancer. The RasGRP3 and phosphoRasGRP3… CONTINUE READING

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