Function of MYO7A in the human RPE and the validity of shaker1 mice as a model for Usher syndrome 1B.

@article{Gibbs2010FunctionOM,
  title={Function of MYO7A in the human RPE and the validity of shaker1 mice as a model for Usher syndrome 1B.},
  author={Daniel M Gibbs and Tanja Diemer and Kornnika Khanobdee and Jane C. Hu and Dean Bok and David S Williams},
  journal={Investigative ophthalmology & visual science},
  year={2010},
  volume={51 2},
  pages={1130-5}
}
PURPOSE To investigate the function of MYO7A in human RPE cells and to test the validity of using shaker1 RPE in preclinical studies on therapies for Usher syndrome 1B by comparing human and mouse cells. METHODS MYO7A was localized by immunofluorescence. Primary cultures of human and mouse RPE cells were used to measure melanosome motility and rod outer segment (ROS) phagocytosis and digestion. MYO7A was knocked down in the human RPE cells by RNAi to test for a mutant phenotype in melanosome… CONTINUE READING

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