Function of GATA transcription factors in preadipocyte-adipocyte transition.

@article{Tong2000FunctionOG,
  title={Function of GATA transcription factors in preadipocyte-adipocyte transition.},
  author={Qiang Tong and Gokhan Dalgin and H. Xu and C N Ting and Jeffrey M. Leiden and G{\^o}khan S. Hotamisligil},
  journal={Science},
  year={2000},
  volume={290 5489},
  pages={
          134-8
        }
}
Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. This effect is mediated, at least in part, through the direct suppression of peroxisome proliferator-activated receptor… 
Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2.
TLDR
The results suggest that GATA-2 maintains a hematopoietic microenvironment by regulating the differentiation of adipocytes, which are the main components of the microenvironment for he matopoiesis.
The transcription factor GATA2 regulates differentiation of brown adipocytes
TLDR
It is reported here that GATA2 is expressed in brown adipocyte precursors, and its expression is downregulated in a differentiation‐dependent manner, and it is shown that reduction of Gata2 promotes brown adipogenesis.
Interaction between GATA and the C/EBP Family of Transcription Factors Is Critical in GATA-Mediated Suppression of Adipocyte Differentiation
TLDR
Results show that in addition to its previously recognized function in suppressing PPARγ transcriptional activity, interaction of GATA factors with C/EBP is necessary for their ability to negatively regulate adipogenesis.
E2Fs regulate adipocyte differentiation.
TLDR
E2Fs represent the link between proliferative signaling pathways, triggering clonal expansion, and terminal adipocyte differentiation through regulation of PPAR gamma expression, and underscores the complex role of the E2F protein family in the control of both cell proliferation and differentiation.
Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation.
  • Y. Hu, G. Davies
  • Biology, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2009
Gata2 Is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice.
TLDR
Findings reveal Gata2 as a crucial rheostat of MSC fate to control osteoblast and adipocyte lineage development and augments adipogenesis and osteoblasts, respectively.
Re-expression of GATA2 Cooperates with Peroxisome Proliferator-activated Receptor-γ Depletion to Revert the Adipocyte Phenotype*
TLDR
It is reported that knockdown of PPARγ expression in 3T3-L1 adipocytes returned the expression of most adipocyte genes to preadipocyte levels, and GATA2, a transcription factor whose down-regulation early in adipogenesis is required for preadendipocyte differentiation and whose levels remain low afterPPARγ knockdown, prevents reversion of mature adipocytes after PParγ depletion.
Overexpression of Chicken Gata2 or Gata3 Suppressed the Transcription of Ppar.GAMMA. Gene
Adipocyte differentiation and its regulatory mechanism in chicken adipogenesis remains unclear. The transcription factors GATA binding protein 2 ( Gata2 ) and GATA binding protein 3 ( Gata3 ) ,which
The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis.
TLDR
Each component of the GATA/FOG complex (GATA-1 and FOG-2) is involved in pRb/E2F regulation, but these molecules have markedly different roles in the control of tissue homeostasis.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 19 REFERENCES
Transcription factor GATA-3 is required for development of the T-cell lineage
TLDR
The results show that GATA-3−/− ES cells can contribute to the development of the mature ery-throid, myelomonocytic and B-cell lineages, but fail to give rise to thymocytes or mature peripheral T cells, suggesting that Gata-3 is an essential and specific regulator of early thymocyte development.
A eukaryotic transcriptional represser with carboxypeptidase activity
TLDR
The cloning of new complementary DNAs that encode the 3T3 preadipocyte factor AEBP1 are reported, and it is demonstrated that AE BP1 expression is abolished during adipocyte differentiation and might represent a new type of transcription factor that regulates transcription by cleavage of factors involved in transcription.
A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila.
TLDR
It is reported that the Drosophila gene serpent (srp) encodes the previously described GATA factor ABF, which implies that some aspects of the molecular mechanisms underlying blood cell development as well as endodermal differentiation are early acquisitions of metazoan evolution and may be common to most higher animals.
Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis.
TLDR
Enhanced expression of C/EBP beta converts multipotential mesenchymal precursor cells into preadipocytes that respond to adipogenic inducers, including dexamethasone and PPAR activators to differentiate into adipocytes.
Differentiation of embryonic stem cells into adipocytes in vitro.
TLDR
The differentiation of embryonic stem cells into adipocytes will provide an invaluable model for the characterisation of the role of genes expressed during the adipocyte development programme and for the identification of new adipogenic regulatory genes.
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
TLDR
The temporal pattern of expression of these three C/EBP isoforms during adipocyte differentiation may reflect the underpinnings of a regulatory cascade that controls the process of terminal cell differentiation.
...
1
2
...