Function of GATA transcription factors in preadipocyte-adipocyte transition.

@article{Tong2000FunctionOG,
  title={Function of GATA transcription factors in preadipocyte-adipocyte transition.},
  author={Qiang Tong and Gokhan Dalgin and H Xu and C N Ting and Jeffrey M. Leiden and G{\^o}khan S. Hotamisligil},
  journal={Science},
  year={2000},
  volume={290 5489},
  pages={
          134-8
        }
}
Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. This effect is mediated, at least in part, through the direct suppression of peroxisome proliferator-activated receptor… Expand
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