Function of GATA transcription factors in hydroxyurea-induced HEL cells

@article{Zhang2001FunctionOG,
  title={Function of GATA transcription factors in hydroxyurea-induced HEL cells},
  author={Shu Zhang and Qi Ye He and Hui Zhao and Chang Yun Gui and Chu Jiang and Ruo Lan Qian},
  journal={Cell Research},
  year={2001},
  volume={11},
  pages={301-310}
}
ABSTRACTHEL cells, a human erythroleukemia cell line, mainly express the fetal (γ)globin gene and trace amount of the embryonic (ɛ)globin gene, but not adult (β) globin gene. Here we show that hydroxyurea (HU) can induce HEL cells to express adult (β) globin gene and lead these cells to terminal differentiation. Results showed in Gel mobility shift assays that GATA factors could specifically bind to the regulatory elements of human β- globin gene, including the proximal regulatory element (the… CONTINUE READING
4 Citations
29 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 29 references

HS3 of the mouse LCR

  • Y Tang, RL Qian
  • Chinese Science Bulletin
  • 1997
1 Excerpt

Development stage-specific factors in the mouse hematopoietic tissues binding to the 5 -flanking cis-acting elements of human -globin gene

  • ZJ Yan, YD Chen, RL. Qian
  • Chinese Science Bulletin
  • 1995

Similar Papers

Loading similar papers…