Function of GATA transcription factors in hydroxyurea-induced HEL cells

  title={Function of GATA transcription factors in hydroxyurea-induced HEL cells},
  author={Shu Zhang and Qi Ye He and Hui Zhao and Chang Yun Gui and Chu Jiang and Ruo Lan Qian},
  journal={Cell Research},
ABSTRACTHEL cells, a human erythroleukemia cell line, mainly express the fetal (γ)globin gene and trace amount of the embryonic (ɛ)globin gene, but not adult (β) globin gene. Here we show that hydroxyurea (HU) can induce HEL cells to express adult (β) globin gene and lead these cells to terminal differentiation. Results showed in Gel mobility shift assays that GATA factors could specifically bind to the regulatory elements of human β- globin gene, including the proximal regulatory element (the… CONTINUE READING
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