Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.

@article{Chin2009FunctionOA,
  title={Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.},
  author={Y. Rebecca Chin and A. C. Toker},
  journal={Cellular signalling},
  year={2009},
  volume={21 4},
  pages={470-6}
}
The serine/threonine protein kinase Akt is a major signal transducer of the phosphoinositide 3-kinase (PI 3-K) pathway in all cells and tissues and plays a pivotal role in the maintenance of cellular processes including cell growth, proliferation, survival and metabolism. The frequent aberrant activation of the PI 3-K/Akt pathway in human cancer has made it an attractive therapeutic target. Numerous studies have provided a comprehensive understanding of the specific functions of Akt signaling… CONTINUE READING

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