Function of β‐amyloid in cholesterol transport: a lead to neurotoxicity

@article{Yao2002FunctionO,
  title={Function of $\beta$‐amyloid in cholesterol transport: a lead to neurotoxicity},
  author={Z X Yao and Vassilios Papadopoulos},
  journal={The FASEB Journal},
  year={2002},
  volume={16}
}
Amyloid β‐peptide (Aβ), Aβ precursor protein (APP), apolipoprotein E (apoE), and elevated cholesterol levels have been linked to Alzheimer's disease (AD) pathology. High cholesterol levels increase APP and apoE expression in human NT2 neuron progenitor cells. A cholesterol‐ rich environment also induces processing of APP, leading to the formation of Aβ and Aβ peptide fragments. Using a novel method, we determined that 1) cholesterol binds to Aβ at a‐secretase cleavage site; 2) Aβ17–40 rather… 
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Why is the amyloid beta peptide of Alzheimer's disease neurotoxic?
  • A. Rauk
  • Biology
    Dalton transactions
  • 2008
In this article, we support the case that the neurotoxic agent in Alzheimer's disease is a soluble aggregated form of the amyloid beta peptide (Abeta), probably complexed with divalent copper. The
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