Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes.

@article{Weinreb2004FunctionblockingIA,
  title={Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes.},
  author={Paul H Weinreb and Kenneth J. Simon and Paul Rayhorn and William J Yang and Diane R Leone and Brian M. Dolinski and Bradley R. Pearse and Yukako Yokota and Hisaaki Kawakatsu and Amha Atakilit and Dean Sheppard and Shelia M. Violette},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 17},
  pages={17875-87}
}
We have generated a panel of potent, selective monoclonal antibodies that bind human and mouse alpha(v)beta(6) integrin with high affinity (up to 15 pm). A subset of these antibodies blocked the binding of alpha(v)beta(6) to the transforming growth factor-beta1 latency-associated peptide with IC(50) values as low as 18 pm, and prevented the subsequent alpha(v)beta(6)-mediated activation of transforming growth factor-beta1. The antibodies also inhibited alpha(v)beta(6) binding to fibronectin… CONTINUE READING

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