Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells.

@article{Shu2010FunctionAR,
  title={Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells.},
  author={Sherry T. Shu and Yasuro Sugimoto and Suling Liu and Hsiang-lin Chang and Weiping Ye and L H Wang and Yi-Wen Huang and Pearlly Yan and Young C. Lin},
  journal={Anticancer research},
  year={2010},
  volume={30 6},
  pages={1937-46}
}
BACKGROUND Protein phosphorylation is one of the essential steps in cell signaling, and aberrant phosphorylation is a common event in human cancer. The expression of receptor type protein tyrosine phosphatase gamma (PTPRG) in normal breast is found to be approximately 50-60% higher than that of breast tumor tissue. Overexpression of PTPRG inhibits anchorage-independent growth and proliferation of breast cancer cells. To understand the tumor suppression characteristics of PTPRG, we studied its… CONTINUE READING